Immuno-suppression and autoimmune diseases are both associated with derangements in the circadian neuroendocrine axis. Once again, it is the critical role of the brain-neuroendocrine axis to regulate and orchestrate the complex immunological interactions that occur at the cellular and tissue levels for the production of an organismal level immunocompetence.
Rather than focusing on specific immuno-modulators such chemokines or lymphkines to boost immuno-reactivity, we focus on resetting circadian neuroendocrine events that organize overall global immunophysiology to treat immuno-suppressed states, such as cancer. Similarly, autoimmune disorders with genetic components manifest as alterations in the neuroendocrine axis which in turn potentiate the underlying disorder.
Consequently, autoimmune diseases may be improved by appropriately resetting specific aberrations in the circadian neuroendocrine axis. Our interventions are not just pharmaceutical compounds but rather therapeutic treatment regimens employing such compounds in a particular manner to reprogram the master control centers in the brain for the production of whole-body immunological status.
